In the field of molecular biology, the P2Y12 protein is found on the surface of blood platelet cells and is an important regulator in blood clotting.P2RY12belongs to a group of G protein-coupled purinergic receptors and is a chemoreceptor for adenosine diphosphate (ADP). The P2Y family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
Human P2Y purinoceptor 12 (P2RY12) ELISA Kit employs a two-site sandwich ELISA to quantitate P2RY12 in samples. An antibody specific for P2RY12 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyP2RY12 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for P2RY12 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of P2RY12 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human P2Y purinoceptor 12 (P2RY12) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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