【Promotion】Abbkine Selected Primary Antibody-Click for Promotion details.
 

Bcl-2 gene (B-cell lymphoma-2) is a member of Bcl-2 family, which is the earliest discovered apoptosis protein. It is an anti-apoptosis protein containing multiple BH domains. It is highly expressed in some cancer cells and selectively plays an anti-tumor role. Bcl-2 family proteins play an important role in the regulation of apoptosis by forming dimers with Bax and dimerizing themselves. When Bcl-2 protein is inhibited, its dimer with Bax decreases, leading to cell apoptosis. When Bcl-2 protein is overexpressed, heterodimers formed by Bcl-2 protein and Bax increase and apoptosis is inhibited. The balance between Bcl-2 and Bax proteins at the cell death signal checkpoint determines the survival or apoptosis of cells.
 

Fig: Bcl-2 and Cell apoptosis
 

We recommend Abbkine selected Bcl-2 antibody for WB, IHC-P and IF experiments in human, rats, mice and chickens.
 

The result:

1) Hela cells; 2) MCF-7 cells; Using Abbkine Bcl-2 monoclonal antibody (ABM0010), WB 1:1000 dilution.

Human oviduct, Using Abbkine Bcl-2 monoclonal antibody (ABM0010) and IHC-P 1:100.

NIH/3T3 cells, Using Abbkine Bcl-2 monoclonal antibody (ABM0010), green, IF 1:100.