Genevac: Post Purification Sample Handling

Hits:1164   Date: 9/17/2015

Genevac, specialists in solvent removal, have developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.

For labs undertaking purification using Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents can be simply, productively and safely carried out in a Genevac centrifugal evaporator (EZ-2, ROCKET, Rocket Synergy or HT Series III). Where the nature of the sample being concentrated can lead to solvent bumping (e.g. natural products) - Genevac's DriPure® technology is proven to completely eliminate this troublesome and time-consuming problem

The evaporation of aqueous acetonitrile (or methanol / ethanol) fractions resulting from 
Reverse Phase HPLC is a widely carried out application on many Genevac evaporator systems.  A multiple stage method has been developed for the EZ-2 evaporator to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.  Alternatively, the unique LyoSpeed™ fast lyophilisation method can be used in Genevac HT series evaporators to produce dry (solvent-free) powders from samples that previously could only be produced as gums and oils.  Recent advances in condenser technology, in particular the high power -75°C cold trap, available on HT Series III and Rocket Synergy evaporators, has led to significant advances in lyophilisation success rates.

During post purification handling - samples typically need to be reformatted from fraction tubes or flasks, into a small vial for compound storage. For this specific time consuming task, Genevac developed SampleGenie™ technology.  SampleGenie™ enables a large volume to be dried (or lyophilised) directly into a small storage vial in a fraction of the time taken by traditional evaporation methods that require you to reformat samples from a flask or multiple tubes into a vial.

For further information on these post purification technologies, including technical articles describing their use, please visit www.genevac.com/purification or contact Genevac on +44-1473-240000 / +1-845-687-5000 / salesinfo@genevac.co.uk

Genevac, now part of SP Scientific, was founded in 1990.  Today the company employs around 65 people, with manufacturing, R&D and marketing headquartered in Ipswich, UK. Genevac offers a comprehensive portfolio of evaporators to suit almost any solvent removal application, purchasing budget or productivity requirement.

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Worldwide HQ

Genevac Ltd.
Farthing Road
Ipswich IP1 5AP
UK

tel. +44-1473-240000 
email salesinfo@genevac.co.uk

www.genevac.com 

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North America HQ

SP Scientific
3538 Main Street
P.O Box 158
Stone Ridge 
NY 12484
USA

Tel: +1.845.687.5315
e: shireen.scott@spscientific.com