AMSBIO: Defined & Controllable Extracellular Matrix for Cell Culture

Biochemically defined and animal-free - Mussel Adhesive Protein based matrix (MAPtrix™) from AMSBIO provides a highly defined and controllable recombinant extracellular matrix (ECM) for cell culture, which can be tailored to the specific needs of particular cell types.
 

MAPtrix mode of action

Low cost and ready-to-use - MAPtrix™ produces a reliable and reproducible protein coating on a wide variety of surfaces including glass, plastic and biological surfaces. Used as a replacement for traditional basement membrane extracts in drug delivery, surface-modified medical device, stem cell and tissue engineering scaffold applications - MAPtrix™ delivers superior cell plating efficiency, improved cell morphology and enhanced cell proliferation.
 

source of Mussel adhesive protein

Mussel Adhesive Protein is a highly desirable substrate for use in a variety of biological and medical applications because of its strong wet adhesive, non-toxic, biodegradable and low immunogenic properties.

MAPtrix™ technology works by incorporating small individual motifs from ECM proteins into recombinant proteins with a backbone of Mussel Adhesive Protein to attach to the substrate, thereby presenting the ECM motif for cultured cells to attach to. Incorporating mix-and-match genetically incorporated bioactive peptides - MAPtrix™ provides an in-vivo-like surface structure, that mimics the native extracellular environment, enabling the maintenance of cells under serum and feeder-free conditions.
 

MCF10A mammary epithelial cells forming an aggregate in MAPtrix™ HyGel. The thick section is about 100 μm. This image demonstrates a potential for morphogenesis, differentiation in basal / myoepithelial cells (CD49f -green) and luminal cells (muc1 - red), nuclei are labeled with DAPI. Image courtesy of Pierre Savagner, Institute of Cancer Research of Montpellier (France)

AMSBIO also offer MAPtrix™ Screen arrays to help scientists to screen a range of ECM motifs to find which ones their cells will adhere to. They can then use these motifs to tailor a defined microenvironment in 2D, or combine the MAPtrix biomimetic with a Polyethylene glycol (PEG) crosslinker to form a hydrogel (MAPtrix™ Hygel) for 3D cell culture.

For further information on MAPtrix™ animal-free recombinant ECM, please visit https://www.amsbio.com/maptrix-recombinant-ecm/ or contact AMSBIO on+44-1235-828200 / +1-617-945-5033 / info@amsbio.com.

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading transatlantic company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO has in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. This expertise in cell culture and the ECM allows AMSBIO to partner with clients in tailoring cell systems to enhance organoid and spheroid screening outcomes using a variety of 3D culture systems, including organ-on-a-chip microfluidics. For drug discovery research, AMSBIO offers assays, recombinant proteins and cell lines. Drawing upon a huge and comprehensive biorepository, AMSBIO is widely recognised as a leading provider of high-quality tissue specimens (including custom procurement) from both human and animal tissues. The company provides unique clinical grade products for stem cell and cell therapy applications these include high quality solutions for viral delivery (lentivirus, adenovirus and adeno-associated virus) in addition to GMP cryopreservation technology.

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Worldwide HQ

AMS Biotechnology (AMSBIO)
184 Milton Park
Abingdon
Oxon OX14 4SE
UK
Tel: +44-1235-828200
Fax: +44-1235-820482
Email: info@amsbio.com
Web www.amsbio.com
 
North American HQ
 
AMSBIO LLC
1035 Cambridge Street
Cambridge
MA 02141
USA
Tel: +1.617.945.5033
Tel: +1.800.987.0985 (toll free)
Email: info@amsbio.com
Web: www.amsbio.com