Cutting-edge Product for Stem Cell Research and Human Embryo Modelling

Amsbio reports that its iMatrix-511 recombinant laminin product has been cited in a recent paper** from researchers at the Stanford University School of Medicine, Stanford, CA, USA as a pivotal tool for stem cell culture and blastoid formation.

This groundbreaking study describes how human blastoid models (stem-cell derived blastocyst-like structures) were used to investigate how human-specific LTR5Hs elements regulate early embryonic development. It provides new unique insights into epiblast differentiation and early embryogenesis.

Cell colonies grown with iMatrix-511 (Image courtesy of the EPLF-Lutofl Lab) ; B: iMatrix-511

iMatrix 511 is a highly purified and refined version of the human recombinant laminin-511 E8 fragment expressed by CHO-S cells. Widely regarded as a gold standard for stem cell culture, iMatrix-511 is an innovative cell culture matrix which permits ES/iPS cells to be maintained in feeder-free culture conditions. Immediately available from stock– iMatrix-511 also enables the passaging of single cells and is proven to provide greater adhesion than full-length Laminin, Vitronectin or Matrigel.

iMatrix-511 can also be used together with Amsbio’s StemFit cell culture media and CELLBANKER cryopreservation series as part of an expanded Stem Cell Synergy solution for ES/iPS cell cultures.

To read more about the Stanford University research study please visit https://www.nature.com/articles/s41586-025-09571-1.

For further information about iMatrix-511 recombinant laminin products please visit https://www.amsbio.com/imatrix-recombinant-laminin-511/ or contact Amsbio on +31-72-8080244 / +44-1235-828200 / +1-617-945-5033 / info@amsbio.com.

Now part of the Europa Biosite group of companies, AMS Biotechnology (Amsbio) is recognized as a leading transatlantic company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products, and services for R&D in the medical, nutrition, cosmetics, and energy industries. Amsbio has in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion, and proliferation. This expertise in cell culture and the ECM allows Amsbio to partner with clients in tailoring cell systems to enhance organoid and spheroid screening outcomes using a variety of 3D culture systems, including organ-on-a-chip microfluidics. For drug discovery research, Amsbio offers assays, recombinant proteins, and cell lines. Drawing upon a huge and comprehensive biorepository, Amsbio is widely recognized as a leading provider of high-quality tissue specimens (including custom procurement) from both human and animal tissues. The company provides unique clinical grade products for stem cells and cell therapy applications. This includes GMP cryopreservation technology, and high-quality solutions for viral delivery.

**  Nature, 647, pp. 238–247 (1st October 2025) - Raquel Fueyo, Sicong Wang, Olivia J. Crocker, Tomek Swigut, Hiromitsu Nakauchi & Joanna Wysocka – see https://www.nature.com/articles/s41586-025-09571-1.

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