For more than four decades, reducing stationary-phase particle size has been exploited to improve chromatographic separation efficiency. Until recently, LC technology had reached a plateau in which the benefits of reducing particle size could not be fully realized due to the negative influence of instrument band spreading and limited pressure range.

The ACQUITY UPLC® System has removed those barriers, enabling columns packed with smaller particles [1.7 – 1.8 µm] to reach their theoretical performance, while precisely delivering mobile phase at pressures up to 1030 bar [15,000 psi], thus providing a new level of chromatographic performance.

The ACQUITY UPLC column family continues to evolve and expand, now including 5 particle substrates [BEH 130Å, BEH 200Å, BEH 300Å, HSS and CSH) and 14 chemistries which are scalable between HPLC and UPLC particle sizes. Additionally, 6 application-directed UPLC chemistries for SEC, amino acid analysis, proteins, peptides, oligonucleotides and glycan analysis are available. With a number of selectivity choices for both small molecule and biopharmaceutical applications, Waters has a UPLC column solution to meet your application needs

ACQUITY UPLC BEH VanGuard