PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. According to an October 2008 press release by the Washington University School of Medicine, the gene is the first gene thought to be involved with clubfoot. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin and it could be associated with autism.The putative encoded mouse and human proteins share 100% identity in the homeodomain and are 88% and 97% conserved in the N- and C-terminal regions, respectively. Intron/exon boundaries are also conserved.

Mouse Pituitary homeobox 1 (PITX1) ELISA Kit employs a two-site sandwich ELISA to quantitate PITX1 in samples. An antibody specific for PITX1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPITX1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PITX1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PITX1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Pituitary homeobox 1 (PITX1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.