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MAS-C

● Activate the column with acetonitrile.

● Add the plasma sample into the above tube

● Add eluent and wait for 3-4 min for precipitation

● Apply vacuum to get the solution through the column and collect the solution

.● Add more solution for elution, collect the eluent and combine collected solution, evaporate solvents and reconstitute the sample with mobile phase, for HPLC or LC-MS analysis.

Characteristic of the Method

● In conventional SPE method, interference matrices are adsorbed and then target compounds eluted, but the MAS are only to adsorb impurities

● MAS employ the sorbent modified with different functional groups that could, simultaneously remove a variety of impurities in one step.

● MAS has good separation ability and selectivity for the proteins, peptides, amino acids, phospholipids, and such biological interference matrix.

● By choosing suitable conditions (solvent and pH), most of the biological interference can be removed, and to ensure strong water-soluble substances tested with more than 70% recovery rate, also for further separation of LC-MS detection.

Ordering Info

Production Spec. Application Package Part No.
MAS SPE cartridge 1mL SPE cartridges, used for basic and neutral substances extraction in Plasma and biological samples 100 MSC-B-0301
1mL 100 MSC-B-0601
1mL SPE cartridges, used for acid substances extraction in Plasma and biological samples 100 MSC-A-0301
1mL 100 MSC-A-0601
MAS 96 well plate 30mg/2ml/well 96 well plate, used for basic and neutral substances extraction in plasma and biological samples. 2 MS-B-0302W
30mg/2ml/well 96 well plate, used for basic and neutral substances extraction in plasma and biological samples, design with a filter membrane (can be used in centrifugation) 2 MS-B-0302W
30mg/2ml/well 96 well plate, used for acid substances extraction in plasma and biological samples. 2 MS-A-0302W
30mg/2ml/well 96 well plate, used for acid substances extraction in plasma and biological samples, design with a filter membrane (can be used in centrifugation). 2 MS-A-0302FW
30mg/2ml/well 96 well plate, used for weak acid substances extraction in plasma and biological samples. 2 MS-WA-0302-W
30mg/2ml/well 96 well plate, used for weak acid substances extraction in plasma and biological samples, design with a filter membrane (can be used in centrifugation) 2 MS-WA-0302-FW

Applications

The most convenient and general approach for 
Propranolol in the Serum with MAS-LC-MS 
Result Contrast from Detection on the Amlodipine in the Serum with MAS-SPE and PPT and SPE Respectiv 
MAS-C Protein Precipitate Columns and SLE on the Drug Metabolism Analysis in the Sample of Serum 
Simultaneous Detection of Glipizide and Glibenclamide with MAS