Human antithrombin, prepared from human plasma, inactivates factor IIa (thrombin) and factor Xa, therefore can be used to determine the anti-FIIa and anti-FXa activities of heparin and LMWHs.

Applications

Human antithrombin can be used in many applications, such as:

1. Anti-factor Xa activity to anti-factor IIa activity ratios of heparin and LMWHs

2. Anti-factor IIa activities and anti-factor Xa activities of heparin and LMWHs

3. As a research reagent to investigate coagulation-related species

Composition

Human antithrombin is in form of white lyophilized powder stored in vials. Each vial contains: Human antithrombin 10 IU; Tris 60.5 mg.

Physical and Chemical Properties

Appearance: white lyophilized powder

Purity: electrophoretic purity

Molecular weight: about 56 kDa

E1cm1%(280 nm): about 10

Specific activity: not less than 6 IU/mg

Standard: 10 IU 

Usage

Reconstitute the entire contents of a vial, dissolve it with 10 mL distilled water to get a solution with concentration of 1 IU/mL human antithrombin, pH 7.4.

Stability and Storage: The lyophilized powder of human antithrombin could be preserved at 2 to 8 °C for 12 months. The 0.25 IU/mL human antithrombin solution could be preserved at 2 to 8 °C for about 1 month.

ADHOC Intertek is a manufacturer and top supplier (over 80% market share the mainland China ) of detection and diagnostic reagents utilized in the production of heparin, LMWH, and chromogenic substrates during the quality control stage. We have accumulated over a decade of successful growth in China and internationally.