Product Overview
Osteoporosis is a metabolic bone disease characterized by the deterioration of bone tissue and low bone mass density leading to bone fragility and risk of fracture. A significant part of osteoporosis research involves the search for new drugs to inhibit osteoclastic bone resorption.

The OsteoAssay™  Human Bone Plate provides the convenience of a high-throughput plate matrix that can be used to quantitatively measure bone resorption.

The OsteoAssay™  plate provides a thin layer of adherent human bone for the culture of primary human or non-human osteoclasts, osteoclast precursors, or immortalized cell lines. Cells can be stained with standard cytochemical (e.g. TRAP) or immunofluorescent techniques. Assays of bone resorption (e.g. EIA of collagen telopeptides), and osteoclast precursor differentiation (e.g. TRAP enzyme activity) can be performed easily by sampling the cell culture supernatant. 

Benefits
Novel - Contains real human bone for more biologically relevant results
Convenient - Ready-to-use plates with human bone chips attached to wells eliminates the need for dentine or bone slices
Simple - Cells can be seeded onto the surface of the OsteoAssay plate and used in traditional cell culture protocols
Flexible - Can be used with a variety of cell types and cell-based assays

Applications
High-throughput analysis of bone resorption
Osteoclast precursor differentiation
Osteoclast enzymatic activity

Content & Storage
Content
 1 x 96-well OsteoAssay Bone Plate

As a worldwide leader supplying the pharmaceutical and biotechnology industries with biopharmaceuticals, Lonza furnishes different markets with state-of-the-art products, services, and research. Our customers range from professionals within the pharmaceutical, biotechnology, academic, and government research industries to manufacturers of consumer and health products, distributors, formulators, and service companies.

Lonza’s Market Offerings:

BioResearch: A leader in groundbreaking research and quality control laboratory testing systems that include tools for endotoxin detection and for the discovery of therapeutics.

Pharma & Biotech: An established supplier to the pharmaceutical industry with global manufacturing and development expertise, advanced technologies and high-quality products.

Consumer Care: A global market leader that draws on science to promote health, wellness, beauty and protection in the areas of Personal Care, Hygiene and Nutrition

Water Treatment: One of the leading suppliers of treatment chemicals, sanitizer feeder systems and other services to the global residential, industrial, commercial and municipial water treatment markets.

Wood Protection: A leading name in industrial pretreatment and surface protection of wood, with the world’s broadest portfolio of wood-protecting chemistries and wood-preservation technologies.

Agro Ingredients: A trusted supplier for the world’s largest agricultural companies with a wide range of offerings, such as custom manufacturing of active ingredients and agrochemical intermediates.

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