Streamlining magnetic bead purifications

We have introduced the MAG and HEATMAG modules with you, the scientists, in mind. These cutting-edge solutions streamline magnetic bead purification in a broad range of molecular and proteomics workflows. The powerful magnets ensure fast bead collection with minimal loss and carryover, and their adjustable height can be customized to your volume requirements for optimal results every time. But that's not all; the HEATMAG module goes one step further by combining magnetic separation with heating capabilities, providing the perfect setting for nucleic acid extraction. It's a truly unique solution that sets INTEGRA apart from the rest.
 
The MAG and HEATMAG modules offer versatility like never before; they can be seamlessly integrated with our pipetting platforms for semi or fully automated workflows, or used as standalone units for manual processing, depending on your requirements. Combining them with the VIAFLO 96,  MINI 96 or VIAFLO 384 pipetting platforms will enable you to process 96 or 384 well plates, or 24 tubes, simultaneously, significantly boosting your productivity. With the ASSIST PLUS pipetting robot, the MAG and HEATMAG modules provide full walk-away magnetic bead purification without the need for costly grippers and robotic arms. This combination opens up new possibilities for your laboratory, making it easier than ever to achieve high quality results.
 
In summary, the key benefits of the MAG and HEATMAG modules are:

• Adjustable magnet heights for bead collection, depending on the volume.
• Exceptional magnet strength, ensuring minimal bead carryover and maximum yields.
• HEATMAG offers a unique combination of magnetic engagement and heating capabilities for lysis or elution.
• Easy integration with the VIAFLO 96, MINI 96 or VIAFLO 384 pipetting platforms.
• Full automation when combined with the ASSIST PLUS pipetting robot.

 
How it works
MAG modules enable automated bead collection using hands-free vertical magnet movement.

Overview

1. Strong magnet for minimal bead loss. The magnetic array can be exchanged on the MAG modules.
2. Automated bead collection using vertical magnet movement.
3. Different labware formats, such as tubes or plates, can be processed.
4. Magnetic bead purification workflows can be fully automated using the ASSIST PLUS pipetting robot.

 
Fast bead capture

Hands-free vertical movement of a strong magnetic array and adjustable bead collection height result in high yields. This enables automated bead collection and optimal magnetic bead capture at both low and high volumes.

Users can switch between different preset heights when using it manually, or benefit from full workflow automation on the ASSIST PLUS pipetting robot.

Heating and magnetic separation in one

HEATMAG combines magnets and heating in one device, supporting workflows at temperatures of up to 65 °C. This unique capability is crucial for tasks like lysis or elution

Versatility

The modules are compatible with a variety of labware types, providing added versatility for a wide range of applications.

Boost productivity for magnetic bead applications

Integration of MAG modules with the ASSIST PLUS pipetting robot allows fully automated, walk-away sample processing, optimizing workflow efficiency and boosting productivity in magnetic bead purification protocols.

Combining the modules with the MINI 96, VIAFLO 96 or VIAFLO 384 enables the simultaneous processing of 96 or 384 wells, or 24 tubes, for high throughput magnetic bead clean-up.

Experience intuitive user interaction

Explore seamless automation with the ASSIST PLUS pipetting robot and VIALAB pipetting software, for effortless control of the MAG modules.To use the modules in combination with the MINI 96, VIAFLO 96, or VIAFLO 384, or on their own, simply connect them to a computer via a USB connection for easy customization, or install the Communication Module to enable Bluetooth communication with the MAG Control App on mobile devices.

Sustainability through longevity and plastic reduction

The longer you can use a device, the better it is for the planet. At INTEGRA, we design our products to ensure low wear and easy serviceability. Moreover, we offer consumable solutions that are low in plastic, for both reservoirs and pipette tips.

Learn more about our sustainability initiatives and goals.

Uses and Applications

PCR clean-up
PCR product purification using magnetic beads for efficient cleanup

Clean-up of reaction mixes after PCR protocols is essential to remove unincorporated primers or dNTPs, so that they do not disrupt subsequent reactions. The MAG module’s adapter for 96 or 384 well PCR plates enables hands-free PCR clean-ups for up to 384 simultaneous reactions per run.

NGS library clean-up
Single-size and double size selection in NGS library preparation

Magnetic beads efficiently isolate DNA fragments based on their size, which is crucial for both single- and double-size selection in NGS library preparation. Magnetic bead purifications with the MAG modules, combined with the precision of INTEGRA's pipetting platforms, provide high yields with minimal bead loss.
 
Nucleic acid extraction
Magnetic beads simplify nucleic acid extraction, isolating DNA and RNA effectively

Isolation of nucleic acids requires selective binding of DNA or RNA from complex biological samples. Magnetic beads offer scalability in in nucleic acid extraction for both volumes and sample numbers. The bead collection height can be changed between the steps, allowing collection at optimal heights during binding/washing (volumes >500 µl) or elution steps (volumes <200 µl). In some extraction protocols, processing steps like lysis and elution require elevated temperatures; the combination of the HEATMAG module’s heating element with the adapter for 1.5 ml tubes is ideal for nucleic acid extractions.
 
Protein enrichment
Concentration of specific proteins in a biological sample using magnetic beads.

The surface of the magnetic beads can also be functionalized with specific ligands – e.g. antibodies for immunoprecipitations – for use in protein analysis. These ligands are chosen to have a high affinity for the target proteins of interest. Repetitive manual pipetting steps can be minimized by combining MAG modules with INTEGRA's pipetting platforms, providing more hands-free time.

Tech Info

Moving liquids in a precise and productive way is core to many tasks of laboratory professionals in the life sciences industry. Since 1965, INTEGRA has been dedicated to developing solutions for pipetting and media preparation, which fulfill the needs of our customers in research, diagnostics and quality control. It is our passion to work side by side with our customers to understand their problems and answer their needs with innovative products. In order to do this, we maintain our own sales and support organizations in several North American, European and Asian countries, as well as a network of over 100 highly trained distribution partners worldwide.

INTEGRA’s engineering and production teams in Zizers, Switzerland and Hudson, NH USA strive to develop and manufacture instruments and plastic consumables of outstanding quality. In recent years, we have focused on developing a new and technologically advanced range of lab devices, which are simple to use and meet the ergonomic needs of our customers. Today we are proud to offer the widest product line of pipettes in the market, spanning a range from single channel mechanical pipettes up to 384 channel electronic benchtop instruments.