Protein tyrosine phosphatase, non-receptor type 22 (lymphoid) is located on the short arm of Chromosome 1 near the telomere (1p13.2) on the Crick (minus) strand. It is 57,898 bases in length and encodes a protein of 807 amino acids (molecular weight 91,705 Da). There are 24 exons in the gene and 21 transcript variants encoding 10 distinct proteins are known. The proteins are located in the cytoplasm.This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T cell receptor signaling pathway.
Human Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) ELISA Kit employs a two-site sandwich ELISA to quantitate PTPN22 in samples. An antibody specific for PTPN22 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPTPN22 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PTPN22 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PTPN22 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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