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Silica Gel Bulk Chromatography Media
Silica Gel Bulk Chromatography Media
Place of Origin:
China
Brand:
Nano-Micro
Model:
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3077 
Updated:
7/19/2017
  • Product Detail
  • Company Profile

    UniSil® is a series of monodisperse spherical porous silica gels used for chromatography, produced by Suzhou Nanomicrotech Co. Ltd. from its unique patented technology that is developed in-house. UniSil® series of products meets the requirements of high performance liquid chromatography (HPLC) analysis in the laboratory and preparative separations in industry scale. The monodisperse spherical porous silica gel has distinct advantages, such as highly uniform particle size, perfect sphericity, outstanding mechanical strength, easy column packing, high column efficiency, good resolution, and low back pressure, UniSil® has already been widely used in analysis and separation of organic compounds, natural products, and large biomolecules.  Nano-Micro is proud to be the leader of monodisperse chromatography silica gel with capability to produce in commercial scale.

    Figure 1. SEM micrographs of UniSil® monodisperse chromatography silica gel

    High uniformity of particle size and perfect spherical shape
    UniSil® silica gel media are made to in precise particle sizes with exceedingly high uniformity and perfect spherical shape (Figures 2 and 3). When compared to other commercial chromatography silica gels ( with broader particle size distribution), UniSil® has great advantages of easy column packing, low back pressure, high column efficiency, good resolution, stable column bed and reduced frit plugging.

    Figure 2. Comparison of UniSil® and well-known international brand chromatography silica gel

    Figure 3. Particle size distribution of UniSil® and well-known international brand chromatography silica gel

    Figure 4. Flow characteristics in chromatography media of different particle size distributions

    Optimal pore structure
    The pore structure of silica gel has a great influence on its mechanical strength, separation ability, and loading capacity. Nano-Micro not only controls precisely the particle size and size distribution of the silica gel, but also optimizes pore structure forming, desired surface area and pore volume. As the result, UniSil® silica gel has high loading capacity, strong mechanical strength, and superior separation capability.

    Unique surface bonding technology

    The selectivity and lifetime of a silica gel are often determined by the bonding phase on its surface and end-capping. In addition to the world leading technology of making silica gel, Nano-Micro has developed unique techniques of surface bonding and end-capping, which enable UniSil® to be used with a broad pH range of application, good separation selectivity, and peak symmetry. To meet customer needs, Nano-Micro also provides a variety of polar and non-polar bonded phase silica gel (C18C8C4PhenylNH2CNDiol).
    Figure 5 showed the separation of various chemical substances by UniSil® 5-120 C18 reverse phase silica gel media, including pyridine (alkaline compound). The high column efficiency and sharp and symmetric peaks indicated the minimal residual silanol groups on the surface (due to good end-capping).

    Figure 5. Chromatographic separation of various compounds by UniSil® 5-120 C18

    Exceptional chemical stability and resistance against acid and base

    Nano-Micro’s unique bonding and end-capping techniques gave UniSil® exceptional resistance to acidic and alkaline environment.  Figure 6 showed a comparison of UniSil® 10-100 C8 with a leading commercial brand, in terms of column efficiency (after alternating elution of columns with acidic and alkaline solutions).  The results indicated that the column packed with UniSil® maintains the column efficiency much better than the other with commercial silica gels, suggesting a stronger resistance against acid and base.

    Figure 6. Comparison of column efficiency, between UniSil® 10-100 C8 (green) and leading commercial brand (red), after treatment with acid and base

    Large scale production capability and lot-to-lot consistency

    State-of-the-art manufacturing facility at Nano-Micro allows a large scale production of UniSil® to meet the demands of industrial separation. Good quality control system also assures the high quality and good lot-to-lot consistency (as shown in Figure 7).

    Figure 7. Lot-to-lot consistency of UniSil® silica gel

    Applications

    Nano-Micro has an in-house application development group with vast experiences. This group provides customers with a lot of technical services, from process development to technical transfer for production (industrial scale). UniSil® silica gel media have been successfully applied to the isolation and purification, including plant extracts (huperzine A, ginkgolide, panax notoginseng saponins), antibiotics(vancomycin, daptomycin, caspofungin, tiacumicin, Pneumocandin B0, cyclosprin, erythromycin), polypeptides (tacrolimus, thymalfasin, bivalirudinand others(cod liver oil, bortezomib, flurbiprofen axetil), etc.

    List of Products

    Nano-Micro supplies spherical silica gel media in the size range of 1.7 to 50 μm, with different pore sizes, meeting the needs of high performance chromatographic (HPLC) analysis in the lab and also preparative separation in industrial scale.

    * Custom-made UniSil® products are available upon request

    a. Particle sizeAny size between 1 and 50 μm;

    b. Pore sizeAny size between 60 and 1000 Å;

    c. Bond phaseSpecial functional groups other than listed above.

    bio-equip.cn
    Nano-Micro Tech is devoted to developing a world-leading technology for making the highest quality and the largest selection of uniformly sized nano- and microparticles. The company is capable of supplying monodisperse particles of any size in the range from 5 nanometers to 1000 microns. Current products include high performance chromatographic media and columns, solid phase extraction (SPE) sorbents, metal scavenger resins, LCD spacer, particle size standards, enzyme support, drug carriers, ACF conductive particles, magnetic particles, fluorescent microspheres, light diffuser particles, cosmetic additive particles and various functional microparticles for other applications.

    The company has a 3500 square meter manufacturing plant and 3000 square meter R&D lab in Suzhou Industrial Park. Microparticles from Nano-Micro Tech have already been broadly used worldwide in biopharmaceuticals, nano and microparticle calibration standards, LED, medical diagnosis, flat panel displays, enzyme catalysis, cosmetics, etc.

    Nano-Micro Tech is a state certified New and High Technology Enterprise, and SGS ISO9001:2008 registered company.
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