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In Vitro-In Vivo Correlation Test System
In Vitro-In Vivo Correlation Test System
Place of Origin:
China
Brand:
Huironghe
Model:
Supplier:
Beijing Huironghe Technology Company
Price:
Hits:
3 
Updated:
7/3/2025
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  • Product Detail
  • Company Profile
    Description
    The actual delivered dose, aerodynamic particle size distribution and lung deposition of inhalers depend on three correlating factors: patients, prescriptions and inhaler devices. Due to the characteristics of inhalers' forms, the current in vitro test methods regulated by Pharmacopoeia as well as the individual different situations, the correlation between in vitro and in vivo is weak and IVIVC studies become necessary. IVIVC conducts in vitro testings by simulating human breath.  
    There are individual differences between different patients, and the actual breathing pattern and inspiratory flow of the patient during inhalation are not consistent with the set flow in the in vitro test, which affects the drug distribution in the lungs and leads to inconsistent results in the in vitro test. 

    Features
    This instrument could simulate human breathing in the in vitro test, which makes the results more consistent with the actual situation and can be analyzed. IVIVC studies enhance the consistency evaluation of inhalers and bioequivalence.

    Specification

    Compressed air flow rate

    0~100L/min

    Simulate peak inspiratory and expiratory flow

    0~100L/min

    Increased flow rate

    0-15L/s2

    Customized breath curve

    Standards
    Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products (2013)
    bio-equip.cn
    Beijing Huironghe Technology Co., Ltd. was founded in 2010 and is situated in the Beijing Economic and Technological Development Zone. As a national high-tech enterprise, the company is dedicated to developing, producing, and providing technical services for scientific research instruments and equipment related to inhalation toxicology, genetic toxicology, and aerosol detection. Its extensive portfolio of offerings includes cutting-edge products such as aerosol inhalation exposure equipment, fully automatic QuEChERS instruments, NGI, and respiratory simulators. With a steadfast commitment to technological innovation at its core, Huironghe strives to provide global customers with the most advanced and high-quality inhalation toxicology equipment and premium technical services, while continuously pushing the boundaries of research and development.
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