Respiratory Disease Modeling and Drug Efficacy Evaluation
Hazard Assessment and Radioactive Substances Protection
Aerospace Medicine
Description
The system can be used to conduct inhalation exposure tests of rodents (rats, mice, guinea pigs, etc.) exposure to gas, vapor, liquid aerosols, solid aerosols, nanoparticle aerosols, etc.
Features
The uniformity and stability deviation of animal respiratory tract for gas is within ±8%, for liquid aerosol is within ±10%, while for dust aerosol is within ±20%, which conforms to technical requirements of OECD guidelines.
Aerosol particle size distribution is MMAD1-3μm, GSD1.5-3.
The temp, humidity, oxygen and carbon dioxide concentration of exposure chamber during test meet requirements of inhalation guidelines.
One cage for one rat inhalation exposure structure can perform 20-80 rats test simultaneously.
Real-time monitor temp, humidity, pressure difference, oxygen and carbon dioxide concentration of exposure chamber during tests. Parameters can be controlled according to requirements of laboratory, e.g., air inlet flow, dilution flow, sampling flow, exhaust flow, exposure time, remaining time, etc.
Standards
OECD Guidelines
① OECD TG 403 Acute Inhalation Toxicity (2009);
② OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009);
③ OECD TG 412 28d Sub-acute inhalation (2018);
④ OECD TG 413 90d Sub-chronic inhalation (2018);
Pesticide Registration Standards
① GB /T 15670.6 ~2017 Toxicological test methods for pesticides registration—Part 6: Acute inhalation toxicity test;
② GB /T 15670.12 ~ 2017 Toxicological test methods for pesticides registration—Part 12: Short-term repeated dose 28-day inhalation toxicity study;
③ GB /T 15670.13 ~2017 Toxicological test methods for pesticides registration—Part 13: Subchronic toxicity study;
④ GB /T 15670.26 ~ 2017 Toxicological test methods for pesticides registration—Part 26: Chronic toxicity study;
Registration of New Chemical Substances by Ministry of Ecology and Environment
① 403 Acute Inhalation Toxicity(2013, 2nd edition);
② 436 Acute Inhalation Toxicity Test:Acute Toxic Class Method(2013, 2nd edition);
③ 412 Sub-acute inhalation:28-days test(2013, 2nd edition);
④ 413 Sub-chronic inhalation:90-days test(2013, 2nd edition);
bio-equip.cn
Shanghai Hongrui Biotechnology Co., Ltd. is a science and technology-based enterprise engaged in the independent research and development of biological engineering instruments and equipment. The company has multiple R&D pipelines, covering the research and production of various types of bioreactors, material handling and separation purification equipment. The manufacture and sale of anaerobic bioreactors are the company's main business. Since its establishment, the company has consistently focused on talent cultivation and technological innovation. By the middle of 2024, the company has obtained more than 40 patent certificates and one international patent certificate.