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- Automatic tangential flow filtration system
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- Automatic tangential flow filtration system
AutoTFF 075 is a flexible and automated lab scale crossflow filtration system that can be used with hollow fibers or cassette filters for concentration, diafiltration or clarification of samples. It is widely used in biological product process, such as antibodies, recombinant proteins,
mRNA, nucleic acids, viral vectors, etc. Its flexible configuration allows for manual operation and highly automated process control. Combined with a comprehensive management system, it is suitable for small-scale process development, process scale up study, and sample preparation
AutoTF 075 system consists of buffer transfer module, recirculation vessel module, feed module, retentate module, filtrate module, filter
holder, control software, etc. The system can be configured according to different process requirement to realize different levels of automation.
Recirculation vessel
● The system comes with a 1L circulation vessel that complies with USP Class VI, with mixing and weighing module at the bottom. The weight is
monitors in real time, and achieve automatic concentration endpoint control and continuouse dialysis.The vessel can be easily emptied with
conical bottom design.
Feed pump
● A peristaltic pump or a low shear force diaphragm pump can be choosed as the feed pump, with a maximum flow rate of 700ml/min, which can
achieve constant flow rate or constant inlet pressure,differential pressure.
Buffer transfer module
● The system can be equipped with transfer pump and inilet valve, which is used for automatic filling of the circulating vessel.
Detector
● The system is equipped with three pressure sensors(2 for module L): inlet, retentate, and permeate, to achieve pressure monitor ing and
calculation of differential pressure and TMP. Conductivity, pH, UV detectors are optional.
Permeate control
● Optional permeate pump allows control of permeate flowrate. It is widely used in microfiltration process. Control the permetate flux can reduce
fouling ot the membrane and slow down the formation of gel layer, which is beneficial for improving the overall process efficiency.
PCV
● The retentate is equipped with an automatic clamp valve(manual valve for module L), which can automatically control the retentate pressure
and achieve automatic adjustment of TMP.
Control software
● The control software can be used for system control, method editing, data recording, user management, equipment calibration, etc. Standard
method modules include clean water flux test, CIP, clarification/concentration, dialysis, harvest/drain, filling, system flushing, etc. Users can
easily create a whole recipe by combining different method mocules.
Predefined method modules
| Method Module | Function |
| Filling | Add a certain amount of liquid to the circulation vessel |
| Water flux test | Can automatically test water flux based on defined pressure/crossflow conditions |
| Clarification/Concentration | Concentrate the feed liquid to the defined volume or concentration factor |
| Diafiltration | Constant volume diafiltration with continuouse feed entill predefined endpoint, eg. |
| Harvest/Drain | Diltiltration volume, conductivity, pH |
| CIP | Harvest the liquid through the harvesting port or outlet valve |
| Flush | Used for system cleaning |
| Pause | Flush the system with water, buffer or other solutions |
| Filling |
AutoTFF™075 Specification
| Dimensions(LxDxH,mm) | 580 x 355 x 640 (filter holder not included)) |
| Electrical requirements | 240VAC, 50-60Hz |
| Weight | 48kg(include 0.1m² filter holder) |
| Power | 150W |
| System language | Chinese, English |
| Ambient temperature | 2-35°C |
| Filtration area | 50cm²- 0.1m²(The specific filtration area can be varied with different filters) |
| Maximum feed pressure | 5bar |
| Minimum recirculating volume | 20ml |
| Process temperature | 2-50°C |
| Feed pump flow rate | 0-700ml/min |
| Retentate pump flow rate | 0-600ml/min |
| Permeate pump flow rate | 0-300ml/min |
| Recirculation vessel volume | 1000ml |
| Stirring speed | 0-300rpm |
| Pressure sensor | Detection range: 0-5Bar |
| Conductivity sensor | Detection range: 0-999.999ms/cm, |
| Temperature sensor | Integrated in conductivity sensor, detection range: 0-99 ° C |
| pH | Detection range: 1-14 |
| Retentate and filtration weighing | 0-6kg |
| Filter holder | 1 ABS multifunctional holder for 50cm ² Capsule capsule or hollow fiber filters with a diameter no more than 50mm 1 0.1m ² Stainless steel holder |
| Tube&Connector | Luer Lock |
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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