S-2765 which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm.
S-2765 is mainly used in anti-FXa activity assay of heparin.
Applications:
S-2765 can be used in many applications, such as:
1. Anti-factor Xa activity to anti-factor IIa activity ratios of heparin and LMWHs
2. Anti-factor Xa activities of heparin and LMWHs
3. Activities of antithrombin and coagulation factors
4. Anti-factor Xa activities of heparin and LMWHs in human plasma
5. Production of kits for automated blood analyzers
6. Evaluation of potential anticoagulants from chemical synthesis, bacterial fermentation and animal tissues
Composition:
S-2765 is white lyophized powder, stored in vials.
Each vial contains: S-2765 10 mg (about 15 μmol); mannitol 60 mg.
Physical and Chemical Properties:
Synonyms: S-2765, FXa substrate
CAS Number: 115388-96-0
Molecular formula: Z-D-Arg-Gly-Arg-pNA·2HCl
Molecular weight: 714.6 Da
Purity: ≥ 99% (HPLC)
Absorption coefficient: A405nm ≤ 0.120 [L/(g·cm)]
Solubility: > 10 mg/mL (in pure water)
Standard: 10mg and 25mg.
Usage:
Reconstitute the entire contents of a vial, dissolve it with 5mL distilled water to get a solution with concentration of 3 mmol/mL S-2765.
Stability and Storage:
The lyophilized powder of S-2765 could be preserved at 2 to 8℃ for at least 24 months.
The 3 mmol/mL S-2765 solution could be preserved at 2 to 8 ℃ for about 1 month.
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