Dry Powder Insufflators™,Penn-Century_specification/price/image

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PennCentury，Penn-Century

Model DP-4，Dry Powder Insufflator™ with disposable 3 ml air syringe

Made of chemically resistant PEEK™ construction, silicone rubber valves, and hollow stainless steel delivery tube for precise administration of dry powders. Accepts all powder sizes. Air supply: 3 ml disposable air syringe （included）. Standard sizes available for intratracheal administration to rat （2"） or guinea pig （3"）.

Penn-Century Dry Powder Insufflators™

part number	model	description
Model DP-4	Dry Powder Insufflator™ with disposable 3 ml air syringe	Made of chemically resistant PEEK™ construction, silicone rubber valves, and hollow stainless steel delivery tube for precise administration of dry powders. Accepts all powder sizes. Air supply: 3 ml disposable air syringe （included）. Standard sizes available for intratracheal administration to rat （2"） or guinea pig （3"）.
DP-4-R	For Rat	Standard size for rat: （2" after 120-degree bend）
DP-4-GP	For Guinea Pig	Standard size for guinea pig （3" after 120-degree bend）
DP-4-C	Custom length	Custom size DP-4 with delivery tube: any length or configuration （straight or with standard 120-degree bend）, as specified by customer.
DP-EXT-R	For Rat	Extra delivery tube for DP-4 for Rat
DP-EXT-GP	For Guinea Pig	Extra delivery tube for DP-4 for Guinea Pig
DP-EXT-C	Custom length	Custom length tips for the Penn-Century Dry Powder Insufflator™ - Model DP-4 may be ordered in any length, straight or with a 120-degree bend, or with custom, flexible delivery tube options. Longer lengths may be inserted into an endotracheal tube or bronchoscope. （Specify dimensions）
SC-X	Sample Chamber Extension	100 mg Sample Chamber Extension - attaches to Model DP-4 for administration of large doses
DPM-APA	Penn-Century Dry Powder Insufflator™/Air Pump Assembly for Mouse	The only light, purely mechanical, manually operated method for intratracheal administration of dry powders to mouse. Includes （1） Penn-Century Dry Powder Insufflator™ for Mouse and （1） Penn-Century Air Pump with adjustable air volume setting （set for mouse at 200 µl）. Insufflator made of chemically resistant PEEK™ construction with removable stainless steel delivery tube sized for intratracheal administration of dry powders to mouse. Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air.
Model DP-4M	Additional DP-4M Dry Powder Insufflator™ for Mouse	Dry Powder Insufflator™ with valve assembly for mouse. PEEK™ construction with silicone rubber valving. Can be used with any animal, including mouse, depending upon delivery tube dimensions. Comes with 23-gauge delivery tube （1.25" after the 120-degree bend）. Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air.
DPM-EXT	Extra delivery tube	Extra delivery tube for DP-4M for Mouse

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Penn-Century accessories for precise intratracheal aerosol administration

part number	model	description
AP-1	Air Pump	Hand-held precision air pipette with spring-loaded thumb button for easy, fast administration of air pulses. Attaches to any size Penn-Century Dry Powder Insufflator™. Plastic construction with rubber square-ring seal. Outlet: male luer slip. Adjustable air volume setting: 0 - 5 ml. Required for use with DP-4M in mice. Recommended for use in rat, or in other applications requiring rapid dosing of multiple subjects with minimal hand motion. Specify animal to be used.
LS-2	Small-Animal Laryngoscope	Designed to clearly illuminate the trachea and epiglottis for intubation and insertion of a Penn-Century MicroSprayer^® or Dry Powder Insufflator™. Now with a fiberoptic LED light source for clear, bright illumination. Each device comes with a custom-made small, tapered stainless steel blade for moving aside the animal's tongue. （Specify animal when ordering）. New easy-grip handle with curved ergonomic shape fits securely in the palm of the hand. Coated with non-slip Santoprene™ rubber. Operates with one 3-volt lithium battery （included）. Autoclavable.
LS-2-M	For Mouse	With blade sized for use in Mouse
LS-2-R	For Rat	With blade sized for use in Rat
LS-2-GP	For Guinea Pig	With blade sized for use in Guinea Pig
LS-2-C	For larger species	Custom blade for larger species. Please specify when ordering.
MIP	Mouse Intubation Platform	For safe, rapid, easy intratracheal intubation of mice. Adjustable posts for stabilizing anesthestized animal. Unique swiveling neck support permits clearer visualization and access to trachea. Made of sterilizable Plexiglass^®/Perspex^® with stainless steel and Delrin^® fittings. Can be attached to any standard lab clamp stand （not included.） NOTE: $50 discount is offered when Platform is purchased with any Penn-Century MicroSprayer^® or Dry Powder Insufflator™.

Paper FOR PenWu Device
You can search in these papers: BJ-PW-M & BJ-PW-R & BJ-PW-FM-M & BJ-PW-FM-R & Bio Jane & PenWu Device for Mouse & PenWu Device for Rat and so on. These papers will show that.
The total impact factor is over 400.

Paper（Liquid）：
1.        https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202007557
Nanoparticle-Mediated Delivery of Inhaled Immunotherapeutics for Treating Lung Metastasis
2.        https://www.pnas.org/doi/full/10.1073/pnas.2102957118
Inhalable nanocatchers for SARS-CoV-2 inhibition
3.        https://pubs.acs.org/doi/10.1021/jacs.1c08017
Renal-Clearable Molecular Probe for Near-Infrared Fluorescence Imaging and Urinalysis of SARS-CoV-2
4.        https://www.nature.com/articles/s41401-021-00808-z
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
5.        https://www.nature.com/articles/s41401-021-00618-3
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells
6.        https://www.sciencedirect.com/science/article/pii/S1742706122003634
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment
7.        https://doi.org/10.1007/s12274-021-4012-9
A chitosan-mediated inhalable nanovaccine against SARS-CoV-2
8.        https://journals.physiology.org/doi/full/10.1152/ajplung.00560.2020
p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model
9.        https://doi.org/10.1002/btm2.10280
Macrophage-targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis
10.      https://doi.org/10.1183/13993003.03697-2020
The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
11.      https://www.hindawi.com/journals/omcl/2022/9300269/  (2022)
MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema
12.      https://www.sciencedirect.com/science/article/pii/S2666386422005641  (2023.1)
A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis
13.      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115697/  (2022.5)
Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis
14.      https://pubs.acs.org/doi/full/10.1021/acsnano.3c00906  （2023.4）
A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis
15.      https://onlinelibrary.wiley.com/doi/10.1002/smll.202300545  （2023.4）
Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis

16.      https://www.sciengine.com/SCLS/doi/10.1007/s11427-022-2314-8;JSESSIONID=63cbf8c9-4345-4b3b-92ba-0efe5f8c34d4  （2023.4）
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization

17.      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759842/
MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema
18. https://doi.org/10.1016/j.biomaterials.2023.122283
Inhalable pH-responsive DNA tetrahedron nanoplatform for boosting anti-tumor immune responses against metastatic lung cancer
19. https://doi.org/10.1021/acsnano.3c08660 （2023.12）
Inhalable Bottlebrush Polymer Bioconjugates as Vectors for Efficient Pulmonary Delivery of Oligonucleotides
20. https://doi.org/10.3390/pharmaceutics15071951 Pharmaceutics 2023, 15(7), 1951;
Systemic Protein Delivery via Inhalable Liposomes: Formulation and Pharmacokinetics
21．https://www.nature.com/articles/s41467-024-50312-1 (2024.7)
Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice
22. https://doi.org/10.1002/adfm.202408767 （2024.9）
Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy
23. https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202311537（2024.1）
ACE2 Receptor-Targeted Inhaled Nanoemulsions Inhibit SARS-CoV-2 and Attenuate Inflammatory Responses
24. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05655-0 （2024.10）
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
25. https://pubs.acs.org/doi/10.1021/acsnano.4c15130 (2025.1)
Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis
26. https://www.sciencedirect.com/science/article/pii/S1818087623000429 (2023.5)
Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance
27. https://doi.org/10.1002/adma.202404264 (2024.6)
Chemically Programmed Hydrogels for Spatiotemporal Modulation of the Cardiac Pathological Microenvironment
28. https://doi.org/10.1007/s11426-024-2600-1 （2025.4）
Construct nucleic acid delivery carriers with excellent antibacterial capabilities for the treatment of bacterial MRSA-induced lung inflammation
29. https://www.sciencedirect.com/science/article/pii/S2090123224002546 （May 2025）
Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis

Dry powder：
1.        https://doi.org/10.1016/j.powtec.2022.117679
Co-achievement of enhanced absorption and elongated retention of insoluble drug in lungs for inhalation therapy of pulmonary fibrosis
2.        https://www.sciencedirect.com/science/article/pii/S0168365923002791  (2023.6)
Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786194/（2022.12）
Development and Pharmacokinetics of a Novel Acetylsalicylic Acid Dry Powder for Pulmonary Administration
4. https://www.sciencedirect.com/science/article/pii/S1818087623000429 (2023.5)
Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance