Mmp11 encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants.
Mouse Stromelysin-3 (MMP11) ELISA Kit employs a two-site sandwich ELISA to quantitate MMP11 in samples. An antibody specific for MMP11 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyMMP11 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MMP11 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MMP11 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Mouse Stromelysin-3 (MMP11) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/mouse-stromelysin-3-mmp11-elisa-kit-kte71012/
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