Mouse Tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) ELISA Kit,Abbkine_specification/price/image

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Pan et al. (1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery.

Mouse Tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) ELISA Kit employs a two-site sandwich ELISA to quantitate TRAILR1 in samples. An antibody specific for TRAILR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTRAILR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TRAILR1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TRAILR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.