IDT: miRNA Regulated Networks Identified in Cystic Fibrosis

The IDT newsletter DECODED features the latest research to rescue the CFTR functionality

 

CORALVILLE, IA – 21 May 2013 – Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers insight into recent research that has unearthed an miRNA-regulated network implicated in the pathogenesis of Cystic Fibrosis (CF). Described in the April edition of DECODED, the international IDT customer newsletter, optimized DIG-labeled DsiRNAs (IDT) were used to develop a novel, enhanced approach for oligonucleotide delivery. Using this delivery technology, researchers led by Dr Paul McCray and Dr Beverly Davidson (Department of Pediatrics, Carver College of Medicine, University of Iowa, IA, USA) showed that the introduction of an miR-138 mimic, developed by IDT, resulted in knockdown of the transcriptional regulator SIN3A, subsequently leading to improved CFTR anion channel functionality on the cell surface, and a partially rescued phenotype.

 

The discovery sheds light on a previously unrecognized mechanism of CFTR processing, and opens up exciting possibilities for novel therapeutic targets in CF. Dr McCarthy commented on the strength of the collaboration with IDT, observing how the quality of the oligos remained intact for the entirety of the experiments, and provided them with “a really robust tool to look at the questions we were asking”. 

 

To read the complete article, please see the April 3.2 issue of DECODED.

 

For more information please visit www.idtdna.com. Follow us on twitter @idtdna for real-time updates and insights.

 

About IDT

Integrated DNA Technologies (IDT) is the largest supplier of custom nucleic acids in the world, serving academic, government, and commercial researchers in biotechnology, clinical diagnostics, and pharmaceutical development. IDT's primary business is the manufacture of custom, synthetic DNA and RNA oligonucleotides. Today, IDT synthesizes and ships an average of 36,000 custom oligos per day to more than 86,000 customers worldwide. IDT manufacturing locations include facilities in Coralville, Iowa; San Diego, Calif.; Leuven, Belgium; and Singapore. For more information visit www.idtdna.com.

 

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