USP28: A Master Deubiquitinase Governing Cell Fate and Genome Stability

1. Concept
USP28 is a key deubiquitinase (DUB) that specifically cleaves K48 and K63linked ubiquitin chains. It controls protein stability, DNA repair, cell cycle progression, and tumorigenesis through dynamic structural switching and multilevel regulation.

2. Research Frontier
USP28 acts as a central node in DNA damage response (DDR), replication stress, telomere maintenance, and mitotic fidelity. It exhibits dual roles in tumor suppression and oncogenic progression, making it a promising drug target.

3. Research Significance
• USP28 stabilizes 53BP1, Claspin, and TRF1/TRF2 to preserve genome integrity.
• It regulates G1/S transition and mitotic checkpoint to ensure accurate cell division.
• USP28 drives Wnt/βcatenin and cMyc signaling in colorectal and lung cancer.
• Targeting USP28 via small molecules or PROTACs offers novel cancer therapy.

4. Mechanism and Application
Structure: Nterminal coiledcoil, central catalytic domain, Cterminal regulatory region.
Activity: Prefer K48Ub chains; activated by Ser667 phosphorylation and SUMOylation.
Functions: DNA repair, replication stress response, cell cycle, senescence, metabolism.
Therapeutics: Selective inhibitors, PROTACs, combination strategies.

 

5. Brand Mission
ANT BIO PTE. LTD. delivers highquality antibodies, proteins, and kits to accelerate research in ubiquitination, DNA damage response, and cancer signaling. Our subbrands Absin, Starter, and UA support global drug discovery and mechanistic studies.

6. Related Product List

Product Name	Catalog No.	Type	Core Application
USP28 research antibodies & proteins	N/A	Antibody/Protein	USP28 detection, ubiquitination assay, drug screening

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.