PTEN Antibody Decodes Tumor Suppressor Inactivation and Precision Therapy

1. Literature Information
This work explains how PTEN antibodies enable accurate evaluation of PTEN functional status, guiding targeted therapy and immunotherapy decisions across multiple cancers.

2. Research Background
PTEN inactivation is widespread in human cancers. Loss of PTEN leads to uncontrolled PI3K/AKT signaling, uncontrolled proliferation, metastasis, metabolic reprogramming, and immune suppression.

3. Research Approach
PTENspecific recombinant antibodies enable IHC detection of expression level and localization. Reduced or absent staining indicates functional loss.

4. Research Outcomes
• PTEN loss predicts benefit from PI3K/AKT/mTOR inhibitors.
• PTENdeficient tumors respond poorly to immune checkpoint inhibitors.
• Combined IHC for PTEN, PDL1, and CD8 improves treatment stratification.
• Nuclear PTEN loss indicates genomic instability and PARP inhibitor sensitivity.

5. Product Empowerment
ANT BIO PTE. LTD. offers PTEN Recombinant Rabbit mAb (S0B2105).
• Highly sensitive and specific for human PTEN.
• Validated for IHC, WB, and IF.
• Stable recombinant expression ensures reproducibility.
• Essential tool for cancer diagnosis and targeted therapy guidance.

6. Brand Mission
ANT BIO PTE. LTD. supplies premium life science reagents supporting tumor suppressor research, drug development, and precision oncology. Our Starter, Absin, and UA brands serve researchers worldwide.

7. Related Product List

Product Name	Catalog No.	Type	Core Application
PTEN Recombinant Rabbit mAb	S0B2105	Recombinant Rabbit mAb	Tumor pathology, signaling research, therapy guidance

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
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