Nano-Micro offers a series of hydrophobic interaction chromatography (HIC) media for high efficiency separation and purification of proteins and peptides. HIC is used to separate proteins on the basis of relative hydrophobicity. The unique feature of HIC is that proteins bind at high salt concentration and elute at low salt concentration. While in reversed phase column chromatography (RPC), desorption is often promoted by the addition of an increasing amount of organic solvent. Therefore gentle binding and elution condition of HIC allows a better retaining of the biologic activity of the target protein than RPC in which organic solvents are applied.  The strength of the hydrophobic interaction is influenced strongly by the nature of the salt components in the mobile phase. The salt concentration needed depends on the protein hydrophobicity and solubility. HIC is particularly attractive for protein purification after ion exchange and affinity chromatography, where the sample with high salt concentration can often be applied directly to HIC. By combining HIC with ion exchange or affinity chromatography, the purification of biomolecules can be completed efficiently.

 

Highly uniform particle size

Uni®HIC are designed to deliver high resolution and high recovery for both lab and large-scale purification. Highly uniform particle sizes of 15, 30, or 80 μm with a narrow particle size distribution are available.

Superior chemical and pH stability

Comparison of column efficiency after treatment with acid and base

High Binding Capacity

Dynamic binding capacity (DBC) of Nano-Micro and competitor HIC resins

Products List

Nano-Micro Tech is devoted to developing a world-leading technology for making the highest quality and the largest selection of uniformly sized nano- and microparticles. The company is capable of supplying monodisperse particles of any size in the range from 5 nanometers to 1000 microns. Current products include high performance chromatographic media and columns, solid phase extraction (SPE) sorbents, metal scavenger resins, LCD spacer, particle size standards, enzyme support, drug carriers, ACF conductive particles, magnetic particles, fluorescent microspheres, light diffuser particles, cosmetic additive particles and various functional microparticles for other applications.

The company has a 3500 square meter manufacturing plant and 3000 square meter R&D lab in Suzhou Industrial Park. Microparticles from Nano-Micro Tech have already been broadly used worldwide in biopharmaceuticals, nano and microparticle calibration standards, LED, medical diagnosis, flat panel displays, enzyme catalysis, cosmetics, etc.

Nano-Micro Tech is a state certified New and High Technology Enterprise, and SGS ISO9001:2008 registered company.