Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. CACNA2D2 （calcium voltage-gated channel auxiliary subunit alpha2delta 2)encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by CACNA2D2 undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in CACNA2D2 are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in CACNA2D2 are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

The antibody detects CaVα2δ2.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000.

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