Calcium binding proteins are an important component of calcium mediated cellular signal transduction. CABP1（calcium binding protein 1) encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by CABP1 regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. CABP1 is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms.

The antibody detects CABP.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000.

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