Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and contain an amino-terminal kinase domain followed by a central proline/serine rich domain and a highly conserved carboxy-terminal domain. The roles of ULK1 and ULK2 in axon growth have been linked to studies showing that the kinases are localized to neuronal growth cones and are involved in endocytosis of critical growth factors, such as NGF . Yeast two-hybrid studies found ULK1/2 associated with modulators of the endocytic pathway, SynGAP and syntenin . Structural similarity of ULK1/2 has also been recognized with the yeast autophagy protein Atg1/Apg1 . Knockdown experiments using siRNA demonstrated that ULK1 is essential for autophagy , a catabolic process for the degradation of bulk cytoplasmic contents . It appears that Atg1/ULK1 can act as a convergence point for multiple signals that control autophagy , and can bind to several autophagy-related (Atg) proteins, regulating phosphorylation states and protein trafficking .

ULK1 Polyclonal Antibody detects endogenous levels of ULK1 protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-p: 1:100-1:300, ELISA: 1:40000. Not yet tested in other applications.

ULK1 Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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