The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. MNT encodes a protein member of the Myc/Max/Mad network. Max-binding protein MNT has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Max-binding protein MNT is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. Max-binding protein MNT represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

MNT Polyclonal Antibody detects endogenous levels of MNT protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000, ELISA: 1:40000. Not yet tested in other applications.

MNT Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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