GaTx1, Selective blocker of CFTR channels The GaTx1 peptide was originally isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx1 is a potent and selective inhibitor of CFTR, an anion selective channel belonging to the ABC transporter superfamily. It was shown to block CFTR channels in a state dependent manner by acting from the internal face of the channel and it is supposed to be a non competitive inhibitor of ATP-dependent channel gating. GaTx1 is a valuable tool to explore the function of CFTR. GaTx1 technical information AA sequence: Cys1-Gly-Pro-Cys4-Phe-Thr-Thr-Asp-His-Gln-Met-Glu-Gln-Lys-Cys15-Ala-Glu-Cys18-Cys19-Gly-Gly-Ile-Gly-Lys-Cys25-Tyr-Gly-Pro-Gln-Cys30-Leu-Cys32-Asn-Arg-NH2 Disulfide bonds between: Cys1-Cys18, Cys4-Cys25, Cys15-Cys30, and Cys19-Cys32 Length (aa): 34 Formula: C147H224N46O47S96 Molecular Weight: 3674.2 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: not available Source: Synthetic Purity rate: > 98 % http://www.smartox-biotech.com/en/chloride-channel/265-gatx1

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