ω-Conotoxin MVIIC / Omega conotoxin MVIIC, Blocker of P/Q and N-type Ca2+ channels ω-conotoxin MVIIC (omega conotoxin MVIIC) has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats. ω-conotoxin MVIIC technical information AA sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2 Disulfide bonds: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26 Length (aa): 26 Formula: C106H178N40O32S7 Molecular Weight: 2750.20 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [147794-23-8] Source: Synthetic Purity rate: > 97 % See also conotoxin GVIA, conotoxin MVIIA, conotoxin SO3 http://www.smartox-biotech.com/en/calcium-channel/157--conotoxin-mviic-

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