μ Conotoxin PIIIA, Blocker of Nav1.4 channels μ-Conotoxin PIIIA (mu-conotoxin PIIIA) has been isolated from the venom of the cone Conus purpurascens. μ-conotoxin PIIIA demonstrates a higher affinity for the mammalian muscle sodium channel Nav1.4 (IC50 ~ 44 nM) than for the CNS Nav1.2 subtype (IC50 ~ 640 nm). μ-Conotoxin PIIIA blocks more irreversibly amphibian muscle sodium channels than mammalian ones. μ-Conotoxin PIIIA technical information AA sequence: H-pGlu-Arg-Leu-Cys4-Cys5-Gly-Phe-Hyp-Lys-Ser-Cys11-Arg-Ser-Arg-Gln-Cys16-Lys-Hyp-His-Arg-Cys21-Cys22-NH2 (Disulfide bonds between Cys4-Cys16, Cys5-Cys21 and Cys11-Cys22) Length (aa): 22 Formula: C103H165N40O28S6 Molecular Weight: 2604.10 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: Source: Synthetic Purity rate: > 97 % See also conotoxin CnIIIC and conotoxin GIIIB. http://www.smartox-biotech.com/en/sodium-channel/97-conotoxin-piiia

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