ω-CONOTOXIN GVIA / Omega conotoxin GVIA, Selective blocker of Cav2.2 channel ω-conotoxin GVIA (omega conotoxin GVIA) has been isolated from the venom of the cone Conus geographus. ω-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically voltage-dependent N-type Ca2+ channels Cav2.2 channel with an ED50 of 68pM. ω-conotoxin GVIA technical information AA sequence: H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2 Hyp: hydroxyproline (Disulfide bonds between Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26) Length (aa): 27 Formula: C120H182N38O43S6 Molecular Weight: 3036.05 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [106375-28-4] Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/calcium-channel/181-omega-conotoxin-gvia

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