PepSets peptide libraries are the rapid and cost effective solution for an immense range of bioactivity screening purposes.
Introduction to PepSets
Peptide libraries are a powerful tool in biological research for screening large numbers of peptides in the search for the few, critical bioactive peptides.
Mimotopes PepSets are custom-synthesized peptide libraries supplied unpuried for fast, efficient screening work. These sets of chemically synthesized individual peptides are made on a small scale using Mimotopes’ unique proprietary parallel array synthesis platform. PepSets comprising hundreds, or even thousands of peptides, are rapidly synthesized and shipped within a few weeks of ordering.
Initial screening can be done with peptides of sufficient purity for the purpose, rather than with highly puried peptides which are relatively expensive and slow to manufacture. In accord with this idea, Mimotopes’ peptide libraries are made on a small scale, subsequently progressing to larger quantities, or purifying the peptides, when it is known which peptides are going to be useful in detailed studies. This approach represents a huge time and cost saving for the user.
For users who require libraries of puried peptides, Mimotopes also offers a conventional puried custom peptide service.
How are PepSets Used
Peptide Libraries are used for diverse purposes, from peptide epitope mapping and structure-activity studies, to the search for peptide “drugs”.
PepSets are ideal for T cell epitope searching, because T cell epitopes are by nature short linear peptides from the primary protein sequence. They are also appropriate for scanning the primary sequence of proteins for linear, or “continuous”, antibody-dened epitopes. Where a bioactive sequence is already known, PepSets provide the ideal primary set of analogs for screening in structure-activity relationship (SAR) studies, also known as “Analoging”. To discover novel bioactive peptides, a PepSet consisting of many altered sequences, with natural or unnatural amino acid replacements, is synthesized and tested. This can result in the denition of highly promising candidate peptide therapeutics, or in the exclusion of classes of inactive peptide analogs from further study.
For orders, quotes and enquiries, contact us directly.
Mimotopes Asia
Tel: +0086 13621502081
Fax: +0086 0510 83583038-2000
bio-equip.cn
Mimotopes Pty Ltd, spun out from the highly respected research organisation Commonwealth Serum Laboratories ("CSL"), was established in Melbourne, Australia in 1988. Mimotopes is an industry leader in the peptide and discovery chemistry sector. Mimotopes develops, markets and distributes sophisticated biochemical products and services for the biotech and pharmaceutical industries, the life-science sector. The customers range from small labs and universities worldwide, to large multinational drug discovery companies. The Mimotopes has a global customer base with sales offices and distribution channels in the US, UK, Europe, Japan and India. Mimotopes uses proprietary technologies in solid phase synthesis, molecule scavenging applications and biomolecular capture and immobilization. As a vehicle in the development of enabling technology for drug discovery and new synthetic vaccines, Mimotopes focused on its core expertise in peptide synthesis and the manufacturing of its patented SynPhaseTM solid phase synthesis modules.
Notable Achievements:
Mimotopes is recognized as one of the first combinatorial chemistry companies formed. The pioneering work of Professor Mario Geysen enabled the parallel synthesis of peptides and subsequently small molecules to become mainstream. Mimotopes’ expertise in polymer chemistry has enabled it to launch the most respected and advanced solid phase synthesis platforms for solid phase synthesis of drug-like molecules (SynPhaseTM Lanterns). Mimotopes is the preeminent epitope mapping company covering all forms of B- and T-cell epitope mapping for drug discovery and vaccine research making important contributions in developing diagnostics (e.g. HCV) and vaccine candidates (e.g. HIV, influenza).
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