ExPlain™
A data analysis system for understanding genomics, transcriptomics, proteomics and NGS data through functional classification, promoter analysis, and pathway analysis tools.
ExPlain™ is a unique data analysis system that combines promoter and pathway analysis tools. Using the power of TRANSFAC®’s transcription factor binding site derived positional weight matrices, ExPlain™ enables you to identify transcription factors affecting gene expression in your microarray and RNA-Seq experiments, as well as predict how they, in combination, can induce observed gene expression patterns. With PROTEOME™’s pathway data, you can take your analysis further and gain insight into the key upstream signaling regulators influencing the activity of these transcription factors.
Benefits
• Perform high throughput prediction of transcription factor binding sites
• Model how transcription factors act together to affect gene expression patterns observed in microarray and RNA-Seq experiments
• Understand the cause, not just the effect, of differential expression in response to drug treatment, disease state, environmental conditions, and more
• Identify potential therapeutic targets or biomarkers acting upstream of your differentially expressed gene set
Key Features
• Advanced data management options for processing and filtering your microarray, ChIP-Seq and RNA-Seq data
• Specialized algorithms for optimized transcription factor binding site prediction
• Positional weight matrix algorithms for superior accuracy
• Combined positional weight matrix and pattern matching algorithms for superior sensitivity
• Genetic algorithms for generating complex promoter models
• Discovery algorithms for identifying novel DNA motifs
• Specialized algorithms and tools for advanced network and pathway analysis
• Fully interlinked with TRANSFAC® and PROTEOME™ reports
Access Options
Online
An online subscription provides access to the ExPlain web interface. Online subscriptions are available at the concurrent user, academic / non-profit lab, and institution-wide level. The concurrent user and academic / non-profit lab subscription levels require IP plus username/password authentication. IP only authentication is optionally available for the institution-wide subscription level.
Installed
An installed subscription allows for local installation of the ExPlain relational database and web interface, allowing uploaded data and analysis results to be stored behind your institution’s firewall. Installed subscriptions are only available at the institution-wide level. MySQL and Oracle platforms are supported.
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BIOBASE is a leading provider of expert-curated biological databases, software and services for the life sciences. Our products and services identify relations critical to drug and biomarker discovery as well as improve biomedical research by transforming data into scientific knowledge. Our customers resolve information challenges and achieve better outcomes faster.
Today’s researcher is challenged to successfully navigate the resulting flood of data. BIOBASE provides that solution to biomedical research and offer the scientific results gathered by generations of dedicated scientists. BIOBASE offers a well-structured data, assembled by highly qualified subject-matter experts, organized in an accessible and easily searchable manner that enables researchers to identify connections between disparate pieces of information and to apply that knowledge to their specific topic of interest.
Worldwide HQ
Germany
Halchtersche Strasse 33
D-38304 Wolfenbuettel
Tel: +49 5331 8584 30
Fax: +49 5331 8584 70
USA
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Beverly, MA 01915
Tel: +1 978 922 1643
Fax: +1 978 922 3971
India
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Langford Town, Bangalore 560 025
Tel: +91 80 4257 7000
Fax: +91 80 4257 7030
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