Caspase-8 (Asp374) Recombinant Rabbit mAb (S-1530-30),specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Host	Rabbit
Antigen	Cleaved Caspase-8 (Asp374)
Synonyms	Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE (FLICE); MCH5; CASP8
Immunogen	Synthetic Peptide
Location	Cytoplasm, Nucleus
Accession	Q14790
Clone Number	S-1530-30
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB
Reactivity	Hu
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 掳C as supplied

Dilution

application	dilution	species
WB	1:1000	Hu

Background

Cleaved Caspase-8 (Asp374) is a key protein involved in the extrinsic apoptosis pathway, which is activated by death receptors such as Fas (CD95) and tumor necrosis factor receptor 1 (TNFR1). When cleaved at Asp374, it generates active fragments, including the p18 subunit, which can further activate downstream effector caspases like caspase-3, -6, and -7, ultimately leading to apoptosis. This protein is also implicated in regulating inflammatory necrotic cell death pathways such as necroptosis and pyroptosis.