Klf4, also known as Kr眉ppel-like factor 4, is a transcription factor that plays a crucial role in various biological processes. It is involved in cell differentiation, proliferation, and apoptosis, and is highly expressed in epithelial tissues such as the gastrointestinal tract and skin. Klf4 regulates the expression of numerous genes by binding to specific DNA sequences in their promoters, thereby modulating cellular functions. In the context of stem cell biology, Klf4 is one of the four Yamanaka factors used to reprogram somatic cells into induced pluripotent stem cells (iPSCs), highlighting its significance in cellular reprogramming and regenerative medicine. Additionally, Klf4 has been implicated in maintaining the integrity of the intestinal barrier and has potential implications in cancer development and progression, making it an important target for therapeutic interventions.