SOD2 (acetyl K68) refers to the acetylation of lysine 68 (K68) on superoxide dismutase 2 (SOD2), a mitochondrial antioxidant enzyme critical for neutralizing superoxide radicals and protecting cells from oxidative stress. This post-translational modification, mediated by acetyltransferases such as SIRT3 (which can also deacetylate it), enhances SOD2 activity, improving its ability to scavenge reactive oxygen species (ROS) and maintain mitochondrial function. Acetylation at K68 influences SOD2鈥檚 structural stability and enzymatic efficiency, playing a key role in aging, metabolic regulation, and diseases like cancer, neurodegeneration, and cardiovascular disorders. Dysregulation of SOD2 (acetyl K68) is linked to increased oxidative damage, making it a potential therapeutic target for conditions involving mitochondrial dysfunction and oxidative stress.