Automatic tangential flow filtration system

AutoTFF 075 is a flexible and automated lab scale crossflow filtration system that can be used with hollow fibers or cassette filters for concentration, diafiltration or clarification of samples. It is widely used in biological product process, such as antibodies, recombinant proteins,
mRNA, nucleic acids, viral vectors, etc. Its flexible configuration allows for manual operation and highly automated process control. Combined with a comprehensive management system, it is suitable for small-scale process development, process scale up study, and sample preparation
AutoTF 075 system consists of buffer transfer module, recirculation vessel module, feed module, retentate module, filtrate module, filter
holder, control software, etc. The system can be configured according to different process requirement to realize different levels of automation.
Recirculation vessel
● The system comes with a 1L circulation vessel that complies with USP Class VI, with mixing and weighing module at the bottom. The weight is
monitors in real time, and achieve automatic concentration endpoint control and continuouse dialysis.The vessel can be easily emptied with
conical bottom design.
Feed pump
● A peristaltic pump or a low shear force diaphragm pump can be choosed as the feed pump, with a maximum flow rate of 700ml/min, which can
achieve constant flow rate or constant inlet pressure,differential pressure.
Buffer transfer module
● The system can be equipped with transfer pump and inilet valve, which is used for automatic filling of the circulating vessel.
Detector
● The system is equipped with three pressure sensors(2 for module L): inlet, retentate, and permeate, to achieve pressure monitor ing and
calculation of differential pressure and TMP. Conductivity, pH, UV detectors are optional.
Permeate control
● Optional permeate pump allows control of permeate flowrate. It is widely used in microfiltration process. Control the permetate flux can reduce
fouling ot the membrane and slow down the formation of gel layer, which is beneficial for improving the overall process efficiency.
 
PCV
● The retentate is equipped with an automatic clamp valve(manual valve for module L), which can automatically control the retentate pressure
and achieve automatic adjustment of TMP.
Control software
● The control software can be used for system control, method editing, data recording, user management, equipment calibration, etc. Standard
method modules include clean water flux test, CIP, clarification/concentration, dialysis, harvest/drain, filling, system flushing, etc. Users can
easily create a whole recipe by combining different method mocules.
 Predefined method modules
 

Method Module	Function
Filling	Add a certain amount of liquid to the circulation vessel
Water flux test	Can automatically test water flux based on defined pressure/crossflow conditions
Clarification/Concentration	Concentrate the feed liquid to the defined volume or concentration factor
Diafiltration	Constant volume diafiltration with continuouse feed entill predefined endpoint, eg.
Harvest/Drain	Diltiltration volume, conductivity, pH
CIP	Harvest the liquid through the harvesting port or outlet valve
Flush	Used for system cleaning
Pause	Flush the system with water, buffer or other solutions
Filling

 
 
AutoTFF™075 Specification

Dimensions(LxDxH,mm)	580 x 355 x 640 (filter holder not included))
Electrical requirements	240VAC, 50-60Hz
Weight	48kg(include 0.1m² filter holder)
Power	150W
System language	Chinese, English
Ambient temperature	2-35°C

 
 
 
 
 
 

Filtration area	50cm²- 0.1m²(The specific filtration area can be varied with different filters)
Maximum feed pressure	5bar
Minimum recirculating volume	20ml
Process temperature	2-50°C
Feed pump flow rate	0-700ml/min
Retentate pump flow rate	0-600ml/min
Permeate pump flow rate	0-300ml/min
Recirculation vessel volume	1000ml
Stirring speed	0-300rpm
Pressure sensor	Detection range: 0-5Bar
Conductivity sensor	Detection range: 0-999.999ms/cm,
Temperature sensor	Integrated in conductivity sensor, detection range: 0-99 ° C
pH	Detection range: 1-14
Retentate and filtration weighing	0-6kg
Filter holder	1 ABS multifunctional holder for 50cm ² Capsule capsule or hollow fiber filters with a diameter no more than 50mm 1 0.1m ² Stainless steel holder
Tube&Connector	Luer Lock

 

Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.