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Home >Products> Reagents >Antibody> LATS1/2 (Phospho-Thr1079/1041) Polyclonal Antibody
LATS1/2 (Phospho-Thr1079/1041) Polyclonal Antibody
LATS1/2 (Phospho-Thr1079/1041) Polyclonal Antibody
Origin of place China
Model ABP59095
Supplier Abbkine Scientific
Price
Hits 106
Updated 10/16/2019
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LATS1 (Large Tumor Suppressor Kinase 1) is a Protein Coding gene. Diseases associated with LATS1 include Tetraploidy and Soft Tissue Sarcoma. Among its related pathways are DNA Damage and Mesodermal Commitment Pathway. The protein encoded by LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000, ELISA 1:10000-20000.

LATS1/2 (Phospho-Thr1079/1041) Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at https://www.abbkine.com/product/lats1/2-(phospho-thr1079/1041)-polyclonal-antibody-abp59095/

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