The human ortholog of Dgcr14 is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of human chromosome band 22q11.2. The encoded protein localizes to the nucleus, and the orthologous protein in humans co-purifies with C complex spliceosomes. Multiple transcript variants encoding different isoforms have been found for Dgcr14.

Mouse Protein DGCR14 (DGCR14) ELISA Kit employs a two-site sandwich ELISA to quantitate DGCR14 in samples. An antibody specific for DGCR14 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyDGCR14 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for DGCR14 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of DGCR14 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Protein DGCR14 (DGCR14) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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