The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors are S1P receptors; others are LPA receptors.According to these guidelines, a receptor is to be named with the abbreviation of the natural agonist with the highest potency, followed by a subscripted arabic number. Thus they suggested that the designation EDG5 should be changed to S1P2.

Mouse Sphingosine 1-phosphate receptor 2 (S1PR2) ELISA Kit employs a two-site sandwich ELISA to quantitate S1PR2 in samples. An antibody specific for S1PR2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyS1PR2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for S1PR2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of S1PR2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Sphingosine 1-phosphate receptor 2 (S1PR2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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