Tripeptidyl-peptidase 1 is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity.It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.

Mouse Thrombus precursor protein (TpP) ELISA Kit employs a two-site sandwich ELISA to quantitate TpP in samples. An antibody specific for TpP has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTpP present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TpP is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TpP bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Thrombus precursor protein (TpP) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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