Product Description (Precision Dynamic Inhalation Exposure System)
The Small Animal Precision Dynamic Inhalation Exposure System is designed for nose-only or oronasal inhalation exposure studies in rodents (such as rats, mice, guinea pigs, etc.) to various inhalable substances including gases, liquid aerosols, dust aerosols, nanoparticle aerosols, smoke, and more.
The system features fully automated control, real-time monitoring of the exposure environment, online aerosol concentration monitoring with feedback control, and real-time sample collection. Equipped with a high-precision control system, it achieves industry-leading uniformity and stability in aerosol concentration.
Features 

• Automated Operation：Features experiment management and rapid parameter setup; One-click start and fully automated operation.
• Precise Control (Vortex Dilution Method): High-precision mass flow meters ensure accurate control of gas flows; Sampling flow accuracy: 0.01 L/min, guaranteeing measurement accuracy.
• Assessment of Actual Animal Inhaled Dose:  The system includes a function to estimate the actual inhaled dose per animal; Displays real-time inhaled dose based on actual concentration and exposure time. 
• Exposure Chamber Constructed from 316L Stainless Steel: Food-grade stainless steel material, corrosion-resistant and durable; Inner surface mirror-polished to minimize drug adhesion.
• Quick Disassembly: Each tier is detachable for easy cleaning; Allows for stackable upgrades; Rotatable base facilitates animal placement.
• Multi-Channel / Multi-Concentration Compatibility: Optional channel configurations (e.g., 6-channel, 12-channel); Enables independent concentration control per port or per tier. 
• Dual-Chamber Design (Directed-Flow): Inner chamber delivers the drug aerosol directly to the exposure ports; Outer chamber collects animal exhaled gases; Separation of inner and outer chambers prevents re-inhalation of exhaled gases.
• Safety Alarms: Environmental parameter anomaly alarms; System malfunction alarms. 
• GLP Compliance: Multi-level user permission management; Audit trail; Electronic signature; Data traceability. 

Compatibility with HOP for Online Respiratory Monitoring 

• Integrates with an online respiratory monitoring system.
• Monitors respiratory changes in animals in real-time during inhalation dosing. 
• Quantifies different levels of respiratory stimulation or suppression caused by the drug.

Applications 

• Drug Evaluation:  Efficacy, pharmacokinetics, and safety evaluation of inhalation drug delivery routes; inhalation immunology research; in vitro cell exposure safety evaluation and primary drug screening.
• Environmental & Health Inhalation Exposure Research: Occupational inhalation exposure risk assessment; PM2.5 particle inhalation exposure studies; Environmental and ecological inhalation exposure research; VOCs inhalation toxicity studies; Gasoline/Diesel engine exhaust inhalation health studies; Nanomaterial particle/dust inhalation exposure safety research.
• Disease Modeling & Research: Lung injury, lung cancer, asthma, COPD modeling; Pneumoconiosis and other occupational disease research. 
• Pesticide & Chemical Inhalation Research: Pesticide inhalation safety evaluation; Chemical inhalation safety evaluation; In vitro cell exposure safety evaluation and primary drug screening; Hazard assessment of chemical aerosols.
• Other: Research on health effects of smoking; Pathogenic microorganism aerosol infection studies; Inhalation exposure hazard assessment in special fields such as military and aerospace medicine.

References
 [1]Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents.Fan Z, Zhou B, Liu Y, Sun W, Fang Y, Lu H, Chen D, Lu K, Wu X, Xiao T, Xie W, Bian Q.AAPS PharmSciTech. 2022 Jan 6;23(1):50. doi: 10.1208/s12249-021-02191-8.
[2]Jushan Zhang, Mo Xue, Rong Pan, Yujie Zhu, Zhongyang Zhang, Haoxiang Cheng, Johan L M Björkegren, Jia Chen, Zhiqiang Shi, Ke Hao“An e-cigarette aerosol generation, animal exposure, and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood” [J]. bioRxiv preprint doi. https://doi.org/10.1101/2022.10.12.511981;
[3]Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu,Xue-Qing Zhang,Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer,[J]ACS Applied Materials & Interfaces,2023-06-24 ,DOI:10.1021/acsami.3c05007

 

TOW-Int, as a high-tech enterprise focusing on the research and development, production and sales of animal experimental equipment and cell research instruments, has always been committed to providing customers with cutting-edge, efficient and stable scientific research solutions.

TOW-Int has been widely recognized by customers at domestic and abroad, mainly due to its focus on the development and manufacturing of clinical animal experimental equipment, as well as many years of experience in the field of animal science experimental research. The company is committed to breaking the monopoly of foreign products, establishing a proud brand of Chinese manufacturing, and providing accurate solutions for global customers.