Product Description (NOE)
The small animal nose-only exposure system is suitable for nose-only administration and inhalation exposure experiments on mice, rats, guinea pigs, and other experimental animals. The system has good air tightness and uniform exposure concentration. It is suitable for nose-only inhalation contamination experiments of inhalable substances such as liquid aerosol, dust aerosol, nanoparticle aerosol, and smoke. The system can ensure the consistency of the inhaled exposure dose of animals in the same experimental group, realize online concentration detection of aerosols and real-time online sampling, and adopt a high-precision control system to ensure the uniformity and stability of exposure.
The animal exposure system can test various substances, including drugs, air pollutants, PM2.5, organic substances, industrial hygiene, agricultural chemicals, etc. It can carry out acute and chronic contamination, hypobaria, hyperbaria, hypoxia, hyperoxia and other gas exposure experiments. For the economic version, please click here.
Features
· Double-chamber Design of Exposure Tower
Experimental channel: standard 24-channel configuration, 12 channels per layer, divided into upper and lower layers. Stackable upgrades are possible
Each layer is removable for easy cleaning
Material: Stainless steel
It has a double-chamber design; the inner chamber is a drug aerosol, and the aerosol is directly transported to the channel; the outer chamber collects the exhaled gas of the animal. Separation of inner and outer cavities to prevent re-inhalation of exhaled air by animals
· Aerosol Monitoring and Control
Comprehensive monitoring of environmental indicators and system operation indicators
Monitoring indicators: temperature, humidity, oxygen concentration, carbon dioxide concentration, pressure, drug concentration, aerosol particle size distribution (optional), etc.
· Exhaust Gas Treatment & Poisoning Chamber
It has a professional multi-stage exhaust gas treatment module, and the exhaust gas can meet the laboratory safety emission requirements after treatment. Provide a contamination chamber to ensure the safety of experimenters
· Security Alarm
Environmental indicators abnormal alarm: too low oxygen concentration, too high carbon dioxide will lead to animal death. When the set safety is exceeded, the system automatically starts an alarm. Alarm setting parameters: oxygen concentration, carbon dioxide concentration, temperature system abnormal alarm.
· Supported Infected Sample Sources
Support liquid aerosol generator, dust aerosol generator, nanoparticle aerosol generator, PM2.5 enrichment and generator, cigarette smoke generator, SO2/ozone/NO2 gas, pollen, etc.
· Applicable Animals
The small animal nose-only exposure system designed by TOW-Int Tech is flexible in configuration and provides animal immobilizers of different sizes. Standard with mouse, rat/guinea pig accessories, optional components for dogs, rabbits, NHP, and other animals. TOW-Int Tech specializes in providing various experimental animal inhalation drug administration and exposure programs and tailors various exposure systems according to users' needs, including animal systemic inhalation exposure systems, animal oral and nasal inhalation exposure systems, and cell exposure systems, contamination systems, etc.

 

 

Applications
Respiratory disease modelling, drug efficacy evaluation, drug safety evaluation, inhalation toxicology research, environmental safety evaluation, PM2.5 research, chemical and pesticide safety evaluation, radioactive material hazard evaluation, military medicine, aerospace medicine, etc.
Configuration

Name	Model	Description
Nose-only Inhalation Exposure System	NOE-12MR-L	12-channel, Mice and Rats, Liquid Aerosol Exposure
Nose-only Inhalation Exposure System	NOE-12MR-LD	12-channel, Mice and Rats, Liquid Aerosol Exposure and Dry Powder Aerosol Exposure
Nose-only Inhalation Exposure System	NOE-24MR-L	24-channel, Mice and Rats, Liquid Aerosol Exposure
Nose-only Inhalation Exposure System	NOE-24MR-LD	24-Channel, Mice and Rats, Liquid Aerosol Exposure and Dry Powder Aerosol Exposure

Related article: Animal Nose-only Exposure Method and Cell in Vitro Exposure Method: Assisting in the Study of the Effects of Air Pollution on Human Health
References
[1]Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents.Fan Z, Zhou B, Liu Y, Sun W, Fang Y, Lu H, Chen D, Lu K, Wu X, Xiao T, Xie W, Bian Q.AAPS PharmSciTech. 2022 Jan 6;23(1):50. doi: 10.1208/s12249-021-02191-8.
[2]Jushan Zhang, Mo Xue, Rong Pan, Yujie Zhu, Zhongyang Zhang, Haoxiang Cheng, Johan L M Björkegren, Jia Chen, Zhiqiang Shi, Ke Hao“An e-cigarette aerosol generation, animal exposure, and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood” [J]. bioRxiv preprint doi.
[3]Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu,Xue-Qing Zhang,Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer,[J]ACS Applied Materials & Interfaces,2023-06-24 ,DOI:10.1021/acsami.3c05007

TOW-Int, as a high-tech enterprise focusing on the research and development, production and sales of animal experimental equipment and cell research instruments, has always been committed to providing customers with cutting-edge, efficient and stable scientific research solutions.

TOW-Int has been widely recognized by customers at domestic and abroad, mainly due to its focus on the development and manufacturing of clinical animal experimental equipment, as well as many years of experience in the field of animal science experimental research. The company is committed to breaking the monopoly of foreign products, establishing a proud brand of Chinese manufacturing, and providing accurate solutions for global customers.