Application
Nasal Spray FPD Tests
Description
To ensure better drug deposition in nasal cavity rather than lung, nasal products such as nasal sprays generate particles with aerodynamic diameters mostly among 20-200μm. However, there will be 5% (or less) particles with aerodynamic diameters under 10μm generated, and deposited in the lower respiratory tract and lung. It is therefore important to quantify fine particle dose (FPD) generated by nasal sprays.
Features
Cascade impactors are used to capture 0-10μm particles. The combination of cascade impactor with nasal spray expansion chamber is used to measure fine particle dose of drugs in nasal sprays and nasal aerosols.
Specification
1L capacity: used in nasal aerosols to maximize deposition below the top stage.
2L capacity: used in nasal sprays to maximize nebulization and deposition.
5L capacity: for some stronger nasal sprays, additional room is required to be able to generate aerosol plume.
Standards
FDA Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action (2003)
FDA Nasal Spray, Inhalation Solution, Suspension & Spray Drug Products（2002）
Nasal Preparations (Dosage Forms 0676) Ph.Eur. 2021 10.5
bio-equip.cn
Beijing Huironghe Technology Co., Ltd. was founded in 2010 and is situated in the Beijing Economic and Technological Development Zone. As a national high-tech enterprise, the company is dedicated to developing, producing, and providing technical services for scientific research instruments and equipment related to inhalation toxicology, genetic toxicology, and aerosol detection. Its extensive portfolio of offerings includes cutting-edge products such as aerosol inhalation exposure equipment, fully automatic QuEChERS instruments, NGI, and respiratory simulators. With a steadfast commitment to technological innovation at its core, Huironghe strives to provide global customers with the most advanced and high-quality inhalation toxicology equipment and premium technical services, while continuously pushing the boundaries of research and development.
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