For  most soluble protein targets, the antibodies are generated by inoculating  animals with purified, full-length protein. Unfortunately, this approach is not  effective for most multiple-spanning membrane proteins, whose native structures  normally depend on an intact lipid bilayer.
 www.creative-biolabs.com/antibody-development-against-membrane-protein.html

 

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit,chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies [including phage display, bacterial display and yeast display]. We are also professional in conducting in depth antibody humanization and affinity maturation usingphage display and DNA mutagenesis approaches. In addition, OEM services for bulk scale antibody manufacturing, including bacterial production of scFv, diabody, tandem scFv, miniantibody and Fab, and mammalian cell expression of minibody, chimeric IgG and IgG, are also available at the most competitive price in the industry.