Creative Animodel provides a set of in vivo compound distribution assays in support of lead candidates selection. We can assist you to identify the metabolic pathways, potentially targeted organism and elimination mechanisms of your compounds at an early stage. Autoradiographic technique, such as autoradiography, quantitative whole-body autoradiography (QWBA) and microautoradiography, is available to provide high-resolution images of the spatial distribution and match tissue concentrations of drug-related radioactivity throughout the body of laboratory animals. Furthermore, using proprietary software, quantitative data can also be produced. https://www.creative-animodel.com/dmpk/compound-distribution-assays.htmlbio-equip.cn Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemo-induced models using these tumor samples and cell lines.
|
中文
