Organism	Homo sapiens, human
Cell Line Description	Saos-2 (osteosarcoma) is a cell line that was isolated by Fogh et al. in 1973 from a primary osteosarcoma in an 11-year-old Caucasian girl. Saos-2 cells express the 1,25-dihydroxyvitamin D3 receptor and have high basal alkaline phosphatase activity. They express the parathyroid hormone (PTH) receptor and produce cyclic adenosine monophosphate after PTH treatment. These cells do not form tumors when injected subcutaneously into immunocompromised mice. However, when injected into diffusion chambers implanted intraperitoneally in immunocompromised mice, Saos-2 cells produce mineralized matrix, a defining characteristic of osteoblasts. These cells have become a widely accepted model for studying osteosarcoma and bone biology due to their osteogenic properties and ability to produce a bone-like extracellular matrix. Saos-2 cells also exhibit an aneuploid karyotype, lacking several chromosomes but having extra copies of other chromosomes, which is typical of many cancer cell lines. They are negative for mycoplasma and have a robust calcification capacity, making them suitable for use in assays related to mineral deposition.
Tissue	Bone
Disease	Osteosarcoma

 

https://www.creative-biogene.com/support/saos-2-cell-line.html

Creative Biogene

Creative Biogene provides kits, reagents, and services that help researchers explore questions about gene discovery, regulation, and function. Creative Biogene holds a leadership position in the global market and is committed to improving the human condition through biotechnology.
Creative Biogene is a US-based manufacturer and provider of genomics and proteomics products and services for academic and governmental research institutes, pharmaceutical and biotechnology industry.

Our Mission

To become the premier provider of innovative technologies, products, unique tools and services for research discoveries and product development in the areas of biological and biomedical research. Emphasis will be placed on the manufacture and distribution of genomics and proteomics based biological research reagent products of the highest possible quality, which include nucleic acid, protein and antibody based research reagent products and services.