Organism	Homo sapiens, human
Cell Line Description	5637 is a cell line that exhibits epithelial morphology and was isolated from the bladder of a 68-year-old Caucasian male patient with grade II carcinoma. The karyotype of 5637 cells has a modal chromosome number of 67, ranging from 59 to 71. 5637 cells produce and secrete multiple growth factors such as SCF, IL-1, IL-6, G-CSF, and GM-CSF. 5637 cells are tumorigenic and have been shown to induce tumors in nude mice inoculated subcutaneously. Oncogene-wise, 5637 cells are positive for FGFR3, PIK3CA, HRAS, KRAS, NRAS, TERT, and CDKN2A, but negative for TP53, belonging to the molecular bladder cancer subtype luminal. 5637 cells are a valuable tool in cancer research, especially in the study of growth factors, cell division, oncogenes, and bladder cancer.
Tissue	Urinary bladder
Disease	Grade II Carcinoma

https://www.creative-biogene.com/support/5637-cell-line.html

Creative Biogene

Creative Biogene provides kits, reagents, and services that help researchers explore questions about gene discovery, regulation, and function. Creative Biogene holds a leadership position in the global market and is committed to improving the human condition through biotechnology.
Creative Biogene is a US-based manufacturer and provider of genomics and proteomics products and services for academic and governmental research institutes, pharmaceutical and biotechnology industry.

Our Mission

To become the premier provider of innovative technologies, products, unique tools and services for research discoveries and product development in the areas of biological and biomedical research. Emphasis will be placed on the manufacture and distribution of genomics and proteomics based biological research reagent products of the highest possible quality, which include nucleic acid, protein and antibody based research reagent products and services.