Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126
Accession	P08887-1
Amino Acid Sequence	Leu20-Pro365 with Human IgG1 Fc & Avi Tag at C-Terminus
Expression System	HEK293
Molecular Weight	72-95kDa (Reducing)
Purity	> 95 % as determined by SDS-PAGE & SEC-HPLC
Endotoxin	<1EU/μg
Conjugation	Biotin
Tag	Avi Tag, Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.M Hibi, M Murakami, M Saito, T Hirano, T Taga, TKishimoto. Molecular cloning and expression of an IL-6 signal transducer,gp130.Cell. 1990 Dec 21;63(6):1149-57. 2. Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z.Targeting miR-10a-5p/IL-6Raxis for reducing IL-6-induced cartilage cell ferroptosis.Exp Mol Pathol. 2021Feb;118:104570. Cell., 63 (1990), pp. 1149-1157.

Background

The interleukin-6 receptor (IL-6R) comprises an 80-kDa IL-6-binding protein (α chain/CD126) and gp130. CD126, a glycoprotein with the ligand-binding site, is part of the human IL-6R, which spans 468 amino acids, including a signal peptide, extracellular region, transmembrane domain, and a short cytoplasmic domain of 19, 339, 28, and 82 amino acids, respectively. IL-6R is present on multiple myeloma, hepatocellular carcinoma, prostate carcinoma, and epidermoid carcinoma cells. The IL-6/IL-6R pathway drives tumor growth, particularly in gliomas, making IL-6R a drug delivery target and a therapeutic target. Primary human cartilage cells express IL-6R, which is upregulated by IL-6, positioning cartilage cells as direct targets of IL-6.